The molecular jury: deciding whether immature thymocytes should live or die.
نویسندگان
چکیده
منابع مشابه
The molecular jury: deciding whether immature thymocytes should live or die
T he TCR repertoire, initially generated by random rearrangement of TCR ot and [3 loci, is heavily shaped by the thymic selection processes. CD4+CD8 + thymocytes expressing TCRs that will in the peripheral lymphoid tissue recognize foreign antigens presented by self MHC are delivered survival and possibly differentiation signals by self peptide/self MHC complexes in the thymus (1). This process...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1996
ISSN: 0022-1007,1540-9538
DOI: 10.1084/jem.184.2.305